Research & Development


  • A pill of Rybelsus, a Novo Nordisk medicine containing semaglutide, is held by a gloved hand.
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    Courtesy of Novo Nordisk
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    Novo regained weight loss footing in the pill arena — but Lilly is coming

    Eli Lilly has run away with the GLP-1 market. But can Novo Nordisk maintain pole position in the oral space?

    By Alivia Kaylor • March 13, 2026
  • An all-green glass building facade with a logo that reads "MERCK" is displayed on the exterior of the research facility.
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    Alamy
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    Keytruda’s reign continues; pharma’s megadeal drought

    Merck & Co.’s landmark cancer drug is still the industry’s bestseller despite the rise of GLP-1s — and other topics on our radar this week.

    By PharmaVoice Staff • March 13, 2026
  • Trendline

    Artificial intelligence & machine learning

    After years of excited buzz around the potential of artificial intelligence and machine learning, pharma has begun to realize the true implications and potential value of these technologies.

    By PharmaVoice staff
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    Keytruda and Padcev could become cancer’s power couple

    The two blockbusters have made a big difference in bladder cancer survival, but will their chemistry hold up when tested in other types?

    By Alexandra Pecci • March 11, 2026
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    Executives want in, but researchers want out — how pharma’s US job picture is changing

    While academics are eyeing friendlier work opportunities abroad, America’s manufacturing boom is drawing industry leaders to its shores.

    By Alexandra Pecci • March 10, 2026
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    Alamy
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    The first KRAS drugs have been sluggish on the market. Will the next generation fare better?

    The regulatory success of KRAS-targeting therapies marked a watershed moment, but there is room for improvement in the real world.

    By Kelly Bilodeau • March 9, 2026
  • Dr. Rick Baehner, chief medical officer, precision oncology, Exact Sciences
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    Permission granted by Exact Sciences
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    Q&A

    Cancer tests are becoming more precise and guiding pharma R&D

    Abbott’s major takeover of Exact Sciences showcases a rising push to leverage cancer tests in precision oncology therapy and R&D. 

    By March 5, 2026
  • A sign for the Food And Drug Administration is seen outside of the headquarters on July 20, 2020 in White Oak, Maryland.
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    Sarah Silbiger via Getty Images
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    What 3 recent FDA rejections reveal about shifts inside the agency

    The FDA’s approval strategy has been difficult to pin down, but recent decisions provide clues for how some of the most volatile initiatives will play out.

    By Alexandra Pecci • March 4, 2026
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    Paul Morigi / Getty Images via Getty Images
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    Inside the race to thwart the dramatic rise in early-onset colorectal cancer

    The increasingly common disease still presents a major challenge in oncology.

    By Kelly Bilodeau • March 4, 2026
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    J&J’s blockbuster Spravato is setting the stage for managing psychedelics’ risks

    Spravato became a blockbuster despite ketamine’s dangerous abuse history, causing doctors to balance the real-world implications of its use.

    By March 3, 2026
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    How does the FDA really feel about psychedelics? We could soon find out.

    Compass Pathways’ psilocybin-based drug is edging closer to an approval but faces mixed signals from officials.

    By Kelly Bilodeau • Feb. 23, 2026
  • A sign spelling Merck hangs on the side of an office building
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    No one-trick pony in oncology, Merck’s cancer footprint is expanding

    The three key therapeutic approaches Merck is leveraging to craft its next era in cancer care.

    By Feb. 20, 2026
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    Pharma could be on the cusp of finally breaking the blood-brain barrier

    Denali’s brain shuttle technology is poised for a potential landmark approval in April, and other options are gaining ground. 

    By Kelly Bilodeau • Feb. 18, 2026
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    More drugmakers are turning to cancer combos. Will it help patients live longer?

    Researchers are increasingly trying multi-pronged approaches to stop tumors in their tracks, leaving monotherapies to the wayside.

    By Kelly Bilodeau • Feb. 17, 2026
  • Meg Alexander
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    Permission granted by Ovid Therapeutics
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    Q&A // First 90 Days

    Ovid takes another big swing in neuroscience under a new CEO

    After multiple setbacks, the company is chasing a CNS target it believes has “revolutionary” potential.

    By Feb. 13, 2026
  • A sign with Eli Lilly's logo sits outside of the company's headquarters on March 17, 2024 in Indianapolis.
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    Scott Olson via Getty Images
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    Lilly’s $2.4B bet on off-the-shelf cell therapy is part of a wider Big Pharma shift

    The pharma giant’s acquisition of in vivo CAR-T specialist Orna Therapeutics follows similar deals from AbbVie, Gilead, Bristol Myers Squibb and AstraZeneca.

    By Feb. 12, 2026
  • Jordana Blackman, co-founder, CEO, Omnigeniq
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    Permission granted by Omnigeniq
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    Profile

    A protein model designed for space could expand pharma’s definition of ‘druggability’

    A computational biology company that started in space tech is looking to change how biopharma finds disease targets by modeling how proteins behave.

    By Feb. 11, 2026
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    In a tough market, biotechs can be their own worst enemy

    Even with sound science, startups can struggle to make their candidates go the distance.

    By Alexandra Pecci • Feb. 10, 2026
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    New FDA guidance that’s a ‘huge deal’ for clinical trials

    Why using Bayesian statistics could transform trial design for rare diseases and beyond.

    By Kelly Bilodeau • Feb. 10, 2026
  • Brain scans of a person with Alzheimer's are seen in this conceptual image.
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    New diagnostics define drug targets for Alzheimer’s, Parkinson’s and beyond

    Emerging tests offer a bridge to pharma aiming to treat neurodegenerative diseases in their earlier stages.

    By Kelly Bilodeau • Feb. 9, 2026
  • Christine Roth
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    Bayer sets the stage for a pharma comeback

    The pharma giant’s drug sales haven’t wowed in recent years. But that could soon change.

    By Feb. 6, 2026
  • Three people in suits sit on a dias at a Congressional hearing.
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    Kevin Dietsch via Getty Images
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    Big Pharma CEOs set sights on massive growth in years to come

    The CEOs at Johnson & Johnson, Pfizer and Merck have big plans for future revenue even as they face difficult odds in the here and now.

    By Feb. 5, 2026
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    Scott Olson via Getty Images
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    The most valuable up-and-coming GLP-1s

    Late-stage GLP-1 candidates from Eli Lilly, Novo Nordisk and Amgen have a combined net present value of $68 billion.

    By Alivia Kaylor • Feb. 5, 2026
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    Investors crave safer, market-ready biotech bets, widening the early-stage funding gap

    In these difficult financial times, venture capital dollars favor later-stage biotechs, forcing drugmakers with earlier-stage candidates to find alternative funding routes.

    By Feb. 3, 2026
  • Chris Peetz, CEO, Mirum Pharmaceuticals
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    Mirum doubles down on diversified rare disease strategy

    With the purchase of biotech Bluejay, Mirum stays focused on building a company with a broad pipeline and portfolio devoted to rare diseases.

    By Alexandra Pecci • Feb. 3, 2026
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    Year in Preview

    Pharma’s outlook in 2026: Smoother sailing ahead?

    After a turbulent year, the industry has a clearer picture of its new landscape and how to navigate the challenges and opportunities ahead. 

    By Jan. 30, 2026