Affordability programs, like co-pay programs, are highly effective at helping patients initiate therapy by reducing cost barriers. While they also improve fill rates incrementally, affordability programs only address the financial barriers to non-adherence without tackling the behavioral or clinical causes of non-adherence. Given that financial concerns only account for around 25% of non-adherence, there is a missed opportunity for both patients and brands to support patients holistically and address all causes of non-adherence.