Drug Research

Rev Up eCTD Production With Microsystems DocXtools™ at Drug Information Association Annual Meeting

May 23, 2017

Chicago, Ill., May 23, 2017 (Business Wire) — Microsystems, a leading provider of document authoring, editing, formatting and quality control solutions for the life science industry, is launching a new and improved version of DocXtools™ for Life Sciences at the Drug Information Association (DIA) Annual Meeting, June 18–22. DocXtools for Life Sciences dramatically cuts the […]

New Data from Emulate’s Asthma-on-Chip Presented at American Thoracic Society Annual Meeting

May 23, 2017

BOSTON, Mass., May 23, 2017 – Emulate Inc. presented data today that shows expanded functionality in modeling viral infection on the Small Airway Lung-Chip. This advancement opens new opportunities for studying viral-induced exacerbations of asthma using a human-relevant system. The data demonstrates the capability to model human airway tissue on the Small Airway Lung-Chip and […]

Midatech announces progress update on brain cancer therapies

May 22, 2017

Midatech Pharma (AIM: MTPH, Nasdaq: MTP), the international specialty pharmaceutical company focused on developing and commercialising products in oncology, announces that it has selected its preferred candidate for testing in glioblastoma (GBM) brain cancer. The compound is under final evaluation with some key pre-clinical studies to confirm efficacy before being progressed into IND enabling trials […]

Evotec Receives Pre-Clinical Milestone as Part of Its Endometriosis Alliance with Bayer

May 22, 2017

HAMBURG, Germany–(BUSINESS WIRE)–Evotec AG (Frankfurt Stock Exchange: EVT, TecDAX, ISIN: DE0005664809) announced today that its multi-target endometriosis alliance with Bayer has reached another significant pre-clinical milestone, triggering a payment of approx. EUR 5 m to Evotec for the transition of a programme into pre-clinical development for the treatment of endometriosis. This milestone was achieved under […]

Recent Publications Demonstrate Rapid Adoption of SMRT Sequencing for Plant and Animal Transcriptome Analysis

May 22, 2017

MENLO PARK, Calif., May 22, 2017 (GLOBE NEWSWIRE) — A series of recent peer-reviewed scientific publications highlights the growing use of Single Molecule, Real-Time (SMRT®) Sequencing to annotate plant and animal genomes. These reports from the genomics community show that PacBio sequencing consistently detects more genes, alternative splicing events, and other important elements compared with […]

Attune Pharmaceuticals Announces Positive Data from Recent Pre-Clinical Studies for ATN-249, an Oral Plasma Kallikrein Inhibitor for the Treatment of HAE at C1-INH Deficiency Workshop

May 22, 2017

NEW YORK, May 22, 2017 (GLOBE NEWSWIRE) — Attune Pharmaceuticals, a biotechnology company focused on the discovery and development of novel oral small molecule therapeutics for treatment of rare diseases, announced today positive results from preclinical safety studies evaluating ATN-249, a novel orally administered plasma kallikrein inhibitor for the treatment of Hereditary Angioedema (HAE). The […]

Patient Treatment Commences in Cynata’s World First Clinical Trial

May 20, 2017

• First patient with steroid resistant acute graft-versus-host disease (GvHD) treated in Cynata’s phase 1 clinical study of its mesenchymal stem cell (MSC) product, CYP-001 • World first clinical trial using a MSC therapeutic product derived from an induced pluripotent stem cell sourced from a single blood donation from one donor • Transition into active […]

Organovo Presents New Preclinical Data on 3D Bioprinted Human Liver Tissues at World Advanced Therapies and Regenerative Medicine Congress

May 18, 2017

SAN DIEGO, May 18, 2017 (GLOBE NEWSWIRE) — Organovo Holdings, Inc. (NASDAQ:ONVO) (“Organovo”), a three-dimensional biology company focused on delivering scientific and medical breakthroughs using its 3D bioprinting technology, today presented new preclinical data showing extended survival and sustained functionality of its 3D bioprinted human liver tissue when implanted into diseased animal models. This data […]

BioreclamationIVT Appoints Senior Marketing Communications Manager

May 18, 2017

BioreclamationIVT, a leading provider of biospecimens and related services, today announced that it has appointed Lauren Vagnone as senior marketing communications manager. In this newly-created position, Ms. Vagnone will be responsible for leading BioreclamationIVT’s communications campaigns and raising awareness of its product portfolio in the life sciences industry. BioreclamationIVT provides biopharmaceutical companies with specialized in […]

Nativis Publishes Abstract on Voyager System for Patients with rGBM at 2017 ASCO Annual Meeting

May 17, 2017

SEATTLE–(BUSINESS WIRE)–Nativis, Inc., a clinical stage life science bio-electronic company developing non-invasive, safe and highly effective treatments for cancers and other serious diseases, today announced the release of an abstract on its Nativis Voyager® system for use in patients with recurrent glioblastoma multiforme (rGBM). The abstract will be published online during the American Society of […]

Tactiva Therapeutics Presents Positive Data on Novel Dual CD4/CD8 T Cell Receptor in Preclinical Models of Cancer

May 16, 2017

BUFFALO, N.Y., May 15, 2017 /PRNewswire/ — Tactiva Therapeutics, a development stage company targeting a broad range of cancers, announced today positive data on the effects of their novel autologous cellular immunotherapy. Built on a dual enhanced adoptive cell therapy (DEACT™) platform, the company’s engineered CD4/CD8 cells generate a durable supply of CD4 cells with […]

Regen BioPharma, Inc. Sees Additional Positive Results on its Medicinal Chemistry Optimization for Modulating NR2F6 Checkpoint for Treating Cancer and Autoimmune Diseases

May 16, 2017

SAN DIEGO, May 16, 2017 /PRNewswire/ — Regen BioPharma Inc. (OTCQB: RGBP) and (OTCQB: RGBPP) states that progress continues to be achieved by Regen in developing small molecule drugs that activate and inhibit NR2F6. The Company reports that ChemDiv, Inc., Regen’s medicinal chemistry partner, has currently identified three series of compounds which activate NR2F6. These […]

Certara Appoints Sandy Allerheiligen as Sr. VP of Health Economics & Education

May 15, 2017

Dr. Allerheiligen will use her predictive, economic and model-informed drug development expertise to support Certara’s work in quantifying a drug’s value to patients and justifying its cost to payers Certara®, the leading provider of decision support technology and consulting services for optimizing drug development and improving health outcomes, today announced that it has appointed Sandy […]

Isarna Presents Positive Clinical Data for ISTH0036 in Advanced Glaucoma and Preclinical Data Supportive of AMD/DME Potential at ARVO 2017 Annual Conference

May 15, 2017

Munich, Germany, May 15, 2017 – Isarna Therapeutics, the leader in transforming growth factor beta (TGF-β) isoform targeted antisense therapeutics, today announced the presentation of the Phase I safety and efficacy data for its lead candidate ISTH0036, a locked nucleic acid-modified antisense oligonucleotide, in advanced-stage glaucoma patients. Overall, the treatment was safe and well tolerated […]

Selecta Biosciences Announces New Preclinical Gene Therapy Data at the Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT)

May 15, 2017

WATERTOWN, Mass., May 15, 2017 (GLOBE NEWSWIRE) — Selecta Biosciences, Inc. (NASDAQ:SELB), a clinical-stage biopharmaceutical company focused on unlocking the full potential of biologic therapies by avoiding unwanted immune responses, today announced new preclinical data regarding non-immunogenic gene therapies that were presented at the American Society of Gene & Cell Therapy (ASGCT) 2017 Annual Meeting, […]

TRACON Pharmaceuticals Announces Publication in Blood of Preclinical Data Indicating Activity of TRC105 in Acute Myeloid Leukemia and B-cell Acute Lymphoblastic Leukemia

May 12, 2017

SAN DIEGO, May 11, 2017 (GLOBE NEWSWIRE) — TRACON Pharmaceuticals (NASDAQ:TCON), a clinical stage biopharmaceutical company focused on the development and commercialization of novel targeted therapeutics for cancer, wet age-related macular degeneration (AMD) and fibrotic diseases, announced today that preclinical data indicating the potential clinical utility of targeting endoglin in acute myeloid leukemia (AML) and […]

New Preclinical Data Support SGT-001 As A Novel Treatment Approach For Duchenne Muscular Dystrophy

May 12, 2017

CAMBRIDGE, Mass.–(BUSINESS WIRE)–Solid Biosciences announced today that new data from two preclinical studies reinforce the potential of its investigational microdystrophin gene therapy, SGT-001, to be an effective treatment approach for Duchenne muscular dystrophy (DMD). The preclinical data, which were presented at the American Society of Gene and Cell Therapy (ASGCT) 20th Annual Meeting, demonstrated that […]

Pharmaleads Reports Positive Ocular Pain Results with PL265, a Novel Dual Enkephalinase Inhibitor (DENKI), at the ARVO 2017 Annual Meeting

May 12, 2017

Paris, France, 12th May 2017 – Pharmaleads, an emerging pharmaceutical company developing innovative products for the management of acute and chronic severe pain, today announced positive efficacy and safety results of PL265, a novel Dual ENKephalinase Inhibitor (DENKI), in a preclinical study for ocular pain. This study was conducted in collaboration with The Vision Institute […]

Ovid Therapeutics to Present Preclinical Data on TAK-935/OV935 at the Antiepileptic Drug and Device Trials XIV Conference

May 12, 2017

NEW YORK, May 12, 2017 (GLOBE NEWSWIRE) — Ovid Therapeutics Inc., (NASDAQ:OVID) a biopharmaceutical company committed to developing medicines for patients with rare neurological diseases, today announced that it will present preclinical data on TAK-935/OV935, a potent and highly selective cholesterol 24-hydroxylase inhibitor in development for the treatment of rare epileptic encephalopathies, at the Antiepileptic […]

Halo Pharma Announces the Formation of Its Pediatric Center of Excellence for the Development, Reformulation, and Manufacturing of Drug Products in Pediatric Dosage Forms

May 10, 2017

WHIPPANY, N.J.–(BUSINESS WIRE)–Halo Pharma announces the formation of its Pediatric Center of Excellence in support of the development and manufacture of dosage forms tailored for pediatric indications. Halo Pharma has been working closely with pharmaceutical companies to apply its extensive expertise in formulation sciences and its fully integrated manufacturing capabilities across a broad range of […]

Implementing a Study Design Change Late in a Trial for Breast Cancer Indication

May 10, 2017

This eligibility study for a breast cancer indication began as a single-read model with six radiologists assigned. Based on the data submitted, the sponsor identified favorable results when the trial was well underway. Consequently, the sponsor sought a more robust approach, requiring a trial design change involving a double radiology read with adjudication. Now on […]

Rescue Studies: Key Considerations for Getting Your Study Back on Track

May 10, 2017

In this episode, Dr. Steiger talks about rescue studies, specifically when to start thinking about bringing in a new vendor, what capabilities to look for in a vendor, three case studies and more. You can also download a related case study entitled “Implementing a Study Design Change Late in a Trial for Breast Cancer Indication” with the […]

SymCel: Phenotype assays needed for antibiotic resistance

May 8, 2017

8th May 2017: SymCel comments on the pressing need to develop novel antibiotic drugs, as well as better tools for diagnostics and stewardship in this field. The traditional detections principles have been refined, and novel molecular-based assays have emerged, but the standard assays are still based on the traditional ‘Pasteur-era’ of growing bacteria and counting […]

Nativis Research Partner Publishes Findings on New Brain Cancer Treatment in Journal of Neuro-Oncology

May 3, 2017

SEATTLE–(BUSINESS WIRE)–Nativis Inc., a clinical-stage life science bio-electronics company developing non-invasive, safe and highly effective treatments for cancers and other serious diseases, today announced the peer reviewed publication of a research paper in the Journal of Neuro Oncology (JNO) on a novel technology to treat brain cancer. “We continue to be encouraged about our Voyager […]